This paper proposes to identify changes in the processing of osseous materials in the southeastern European Neolithic, beginning with three cases of production by manufacture wear technique (bipartition by abrasion, segmentation with abrasive fibers and perforation by wear technique). The processing of osseous materials is strongly conditioned by their natural anatomic shape which is why a limited array of possible transformation variables would be expected with minimum changes through time. Still, these three types of bone manufacturing techniques are not found throughout the prehistory of this region. Some of these techniques appear on worked osseous materials in Romania and neighboring areas at the beginning of Neolithic and disappear just as suddenly (bipartition by abrasion and perforation) or appear only sporadically (segmentation with an abrasive fiber) by the Early Chalcolithic. Based on experimental reconstructions of the three processing techniques and comparing them with the archaeological assemblages, the study identifies some of the reasons the techniques appear and why they are abandoned afterwards, the advantages and disadvantages of these techniques compared to other transformation schemes and whether they represented some kind of real innovation in the way osseous materials are processed. Starting from these reflections, the study of the hard animal materials industry represents a window through which we can what cultural options were open to the prehistoric communities making these tools and ornaments.